Directed ortho Metalation Studies on Podocarpic Acid Derivatives: Advantageous Use of a LICKOR Base

…, PI Higgs, KC Lee, MR Metzler, PS Rutledge…

Index: Cambie, Richard C.; Higgs, Paul I.; Lee, Kee Chee; Metzler, Michael R.; Rutledge, Peter S.; at al. Australian Journal of Chemistry, 1991 , vol. 44, # 10 p. 1465 - 1477

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Citation Number: 7

Abstract

Abstract Methyl 13-(N, N-diethylcarbamoyl)-12-methoxypodocarpa-8, 11, 13-trien-19-oate (2), 13-(N, N-diethylcarbamoyl)-12, 19-dimethoxypodocarpa-8, 11, 13-triene (8) and N, N- diethyl-2-methoxy-4, 5-dimethylbenzamide (15) were prepared for studies involving lithiation directed ortho to the tertiary amide group, in which the use of a LICKOR base was advantageous. Some dynamic features of the nmr spectra of the amides are discussed. ...