Total chemical synthesis and antitumor evaluation of 4-demethoxy-10, 10-dimethyldaunomycin

J Alexander, I Khanna, D Lednicer…

Index: Alexander, Jose; Khanna, Ish; Lednicer, Daniel; Mitscher, Lester A.; Veysoglu, Tarik; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1343 - 1347

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Citation Number: 5

Abstract

Synthetic studies on anthracycline antitumor antibiotics such as daunomycin (1) and doxorubicin (2) have been pursued intensively. lI2 Present interest is turning increasingly to total synthesis of unnatural analogues inaccessible from fermentation-derived substrates in the hope of producing drugs with significantly altered biological properties. 14 In this context we report here our experiences in the total synthesis and antitumor evaluation of 4- ...