Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII—A new scaffold for designing isoform-selective …

S Carradori, C De Monte, M D'Ascenzio, D Secci…

Index: Carradori, Simone; De Monte, Celeste; D'Ascenzio, Melissa; Secci, Daniela; Celik, Gulsah; Ceruso, Mariangela; Vullo, Daniela; Scozzafava, Andrea; Supuran, Claudiu T. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6759 - 6763

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Citation Number: 22

Abstract

Abstract Salen and tetrahydrosalen derivatives possess metal-chelating properties and have been used as ligands in organic synthesis and as scaffolds for developing therapeutic agents. Fourteen such compounds were synthesized in order to explore their ability to inhibit the zinc enzyme carbonic anhydrase (CA, EC 4.2. 1.1). Human (h) isoforms hCA I, hCA II, hCA IX and hCA XII were included in the investigation. Several aliphatic and aromatic ...