Synthesis of functionalized cyclotriveratrylene analogues with C 1-symmetry and the application for 1, 4-Michael addition of alcohols to unsaturated aryl ketone

JR Song, ZT Huang, QY Zheng

Index: Song, Jing-Ru; Huang, Zhi-Tang; Zheng, Qi-Yu Tetrahedron, 2013 , vol. 69, # 35 p. 7308 - 7313

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Abstract

Abstract C 1-symmetric cyclotriveratrylene analogues 2–8 with various functional groups at one benzene moiety were prepared starting from the selectively demethylated compound 1. Through the chemical resolution, a pair of enantiomers of C 1-symmeric compound 1 could be separated with gram scale. Compound 8, which possessed an N-linked imidazolium unit at the upper rim of the macrocyclic skeleton through a methylene linker, was successfully ...