Tetrahedron

Synthesis and X-ray molecular structure of N-(1-amino-2, 2-dichloroethyl) benzamides

A Guirado, R Andreu, A Zapata, A Cerezo, D Bautista

Index: Guirado, Antonio; Andreu, Raquel; Zapata, Andres; Cerezo, Alfredo; Bautista, Delia Tetrahedron, 2002 , vol. 58, # 25 p. 5087 - 5092

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Citation Number: 8

Abstract

Efficient procedures for the synthesis of N-(1-alkylamino-2, 2-dichloroethyl) benzamides, N- (1-arylamino-2, 2-dichloroethyl) benzamides and N-(1-amino-2, 2-dichloroethyl) benzamides are reported. These compounds are of special interest as intermediates to access new heterocyclic series. N-(2, 2-dichlorovinyl) amides react with primary or secondary alkylamines to yield the title compounds in high to quantitative yields. However, ...