Asymmetric synthesis of α, α-disubstituted α-amino acids by diastereoselective alkylation of camphor-based tricyclic iminolactone
PF Xu, S Li, TJ Lu, CC Wu, B Fan…
Index: Brandl, Melanie; Kozhushkov, Sergei I.; Braese, Stefan; De Meijere, Armin European Journal of Organic Chemistry, 1998 , # 3 p. 453 - 457
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Citation Number: 25
Abstract
... Journal ... J. Org. Chem. ... As anticipated, excellent results were observed as summarized in Table 2. Table 2. Alkylation of Mixtures of Monosubstituted Iminolactones. entry, substrate, R, E +, product, yield a (%), endo/exo b, % de c. 1, 16 + 20, CH 3, C 6 H 5 CH 2, 18a, 80 (88) d, >99:1 ...
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