Structure-activity relationship studies in the field of calcium (II) antagonists. Effect of modifications at the tetrasubstituted carbon of verapamil-like compounds

F Gualtieri, E Teodori, C Bellucci, E Pesce…

Index: Gualtieri; Teodori; Bellucci; Pesce; Piacenza Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1621 - 1628

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Abstract

A number of fluorenyl and diphenylmethane analogues of verapamil, chosen as having the same substituents arranged in different ways around the quaternary carbon, were synthesized in order to evaluate the importance of the stereoisomerism at that point of the molecule. The compounds were tested with the Langendorff technique and coronary perfusion pressure (CPP), left ventricular pressure (LVP), and heart rate (HR) were ...