Tetrahedron

Syntheses of acetylquinolines and acetylisoquinolines via palladium-catalyzed coupling reactions

JY Legros, G Primault, JC Fiaud

Index: Legros, Jean-Yves; Primault, Gaelle; Fiaud, Jean-Claude Tetrahedron, 2001 , vol. 57, # 13 p. 2507 - 2514

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Citation Number: 47

Abstract

Acetylquinolines and acetylisoquinolines were obtained from the corresponding chloro-, bromo-or trifluoromethylsulfonyloxy-heteroaromatics via four different palladium-catalyzed coupling reactions:(i) Stille coupling with tri (n-butyl)-1-ethoxyvinylstannane;(ii) Negishi coupling with 1-ethoxyvinylzinc chloride;(iii) cross-coupling with tri (1-ethoxyvinyl) indium;(iv) Heck arylation of n-butyl vinyl ether.