Zn-mediated, Pd-catalyzed cross-couplings in water at room temperature without prior formation of organozinc reagents

A Krasovskiy, C Duplais…

Index: Krasovskiy, Arkady; Duplais, Christophe; Lipshutz, Bruce H. Journal of the American Chemical Society, 2009 , vol. 131, # 43 p. 15592 - 15593

Full Text: HTML

Citation Number: 129

Abstract

Mix in water, stir. That is all that is required in this new approach to sp3− sp2 cross-couplings between an alkyl iodide and an aryl bromide, both potentially bearing functionality. They react under catalysis by Pd (0) in the presence of zinc powder, aided by a nonionic amphiphile, to give the alkylated aromatic. No organic solvents and no heating; just add water.