New adamantane-based spiro 1, 2, 4-trioxanes orally effective against rodent and simian malaria

C Singh, R Kanchan, U Sharma…

Index: Singh, Chandan; Malik, Heetika; Puri, Sunil K. Journal of Medicinal Chemistry, 2006 , vol. 49, # 9 p. 2794 - 2803

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Citation Number: 49

Abstract

New 6-arylvinyl-and 6-adamantylvinyl-substituted 1, 2, 4-trioxanes (13a-g and 14a, b) have been prepared and evaluated for antimalarial activity against multidrug resistant Plasmodium yoelii nigeriensis in mice by both oral and intramuscular routes. While all the 6-