Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer
DSH Chan, H Yang, MHT Kwan, Z Cheng, P Lee…
Index: Chan, Daniel Shiu-Hin; Yang, Hui; Kwan, Maria Hiu-Tung; Cheng, Zhen; Lee, Paul; Bai, Li-Ping; Jiang, Zhi-Hong; Wong, Chun-Yuen; Fong, Wang-Fun; Leung, Chung-Hang; Ma, Dik-Lung Biochimie, 2011 , vol. 93, # 6 p. 1055 - 1064
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Citation Number: 49
Abstract
G-quadruplexes are non-canonical DNA secondary structures putatively present in the promoter regions of oncogenes in the human genome. The targeting of promoter G- quadruplex structures to repress oncogene transcription represents a potential anticancer strategy. Here, we have used high-throughput virtual screening to identify FDA-approved drug methylene blue (MB) as a promising scaffold for binding the c-myc oncogene G- ...