Design, synthesis, and biological evaluation of alcyopterosin A and illudalane derivatives as anticancer agents

LM Finkielsztein, AM Bruno, SG Renou…

Index: Finkielsztein, Liliana M.; Bruno, Ana M.; Renou, Sergio G.; Moltrasio Iglesias, Graciela Y. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1863 - 1870

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Citation Number: 25

Abstract

The synthesis of alcyopterosin A and a series of new derivatives possessing an illudalane skeleton is described. The DNA binding properties of these compounds have been examined and compared to those of reference drugs using a UV spectroscopy technique. The antitumor activity of selected compounds against a panel of 60 human tumor cell lines was tested in the in vitro anticancer screening of the National Cancer Institute. Redox ...