Journal of the American Chemical Society

Regiospecific total syntheses of (.+-.)-aklavinone and (.+-.)-. epsilon.-pyrromycinone from a common synthon

FM Hauser, D Mal

Index: Hauser, Frank M.; Mal Dipakranjan Journal of the American Chemical Society, 1984 , vol. 106, # 4 p. 1098 - 1104

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Citation Number: 43

Abstract

60 X= CN 6 b X= C02H for many years the only antibiotic known to be derived from aklavinone (la). 3 Beginning in 1975, Oki et al. published a series of papers describing the isolation, characterization, and biological activity of seven new antibiotics with la as the agly~ on.~ One of these, aclacinomycin A (IC) is presently undergoing clinical evaluation since it has been found to have substantial anticancer activity while being less toxic than ...