Synthesis and muscarinic receptor activity of ester derivatives of 2-substituted 2-azabicyclo [2.2. 1] heptan-5-ol and-6-ol

FI Carroll, P Abraham, S Chemburkar…

Index: Carroll, F. Ivy; Abraham, Phillip; Chemburkar, Sanjay; He, Xu-Chang; Mascarella, S. Wayne; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2184 - 2191

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Citation Number: 15

Abstract

The cholinergic hypothesis',* is a major neurochemical base for current Alzheimer's research. This has resulted in a renewed interest in the muscarinic receptor (s) field. As an extension of our study on the structure-activity relationship of muscarinic ligand^,^-^ we prepared the acetate and 2, 2-diphenylpropionate esters of endo-and exo-2-alkyl-2- azabicyclo [2.2. l] heptan-5-01 (1 and 2) and not significantly different and to approximate ...