Synthesis

One-pot synthesis of substituted δ1-pyrrolines through the michael addition of nitroalkanes to chalcones and subsequent reductive cyclization in aqueous media

Y Liang, D Dong, Y Lu, Y Wang, W Pan, Y Chai…

Index: Liang, Yongjiu; Dong, Dewen; Lu, Yumei; Wang, Yan; Pan, Wei; Chai, Yanyan; Liu, Qun Synthesis, 2006 , # 19 p. 3301 - 3304

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Citation Number: 14

Abstract

Abstract A facile and efficient one-pot synthesis of substituted Δ 1-pyrrolines in aqueous media has been developed. Upon treatment with aqueous sodium hydroxide in N, N- dimethylformamide, a range of chalcones underwent room temperature Michael addition reactions with nitroalkanes. The resulting adducts were directly reduced in situ with Zn/HCl (aq) and subsequently underwent an intramolecular cyclization, affording the ...