Effect of tellurium position on the myocardial uptake of radioiodinated 18-iodotellura-17-octadecenoic acid analogs
FF Knapp Jr, PC Srivastava, AP Callahan…
Index: Knapp, F.F.; Srivastava, P.C.; Callahan, A.P.; Cunningham, E.B.; Kabalka, G.W.; Sastry, K.A.R. Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 57 - 63
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Citation Number: 31
Abstract
The effect of tellurium (Te) position on myocardial specificity and retention of fatty acids in which radioiodide is stabilized as a trans-(E)-vinyl iodide has been evaluated in rats. Five analogues of 18-iodo-17-octadecenoic acid (ICH= CH-R-TeR'-COOH) with Te at positions 5, 7, 9, 11, and 13 were prepared by coupling of a trans-diiodoalkene (ICH= CH-RI) with the requisite sodium [(alkoxycarbonyl) alkyl] telluride substrate (NaTe-R'-COOR”; R”= Me or Et ...
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