Palladium-catalyzed Kumada Coupling Reaction of bromoporphyrins with silylmethyl Grignard reagents: Preparation of silylmethyl-substituted porphyrins as a …

…, S Hayashi, F Hino, T Takanami

Index: Sugita, Noriaki; Hayashi, Satoshi; Hino, Fumio; Takanami, Toshikatsu Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10488 - 10497

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Citation Number: 11

Abstract

We have developed an efficient method for preparing silylmethyl-substituted porphyrins via the palladium-catalyzed Kumada cross-coupling reaction of bromoporphyrins with silylmethyl Grignard reagents. We demonstrated the synthetic utility of these silylmethylporphyrins as a multipurpose synthon for fabricating porphyrin derivatives through a variety of transformations of the silylmethyl groups, including the DDQ-promoted ...