Microwave??Assisted Transition??Metal??Catalyzed Synthesis of N??Shifted and Ring??Expanded Buflavine Analogues

…, W Dehaen, E Van der Eycken

Index: Appukkuttan, Prasad; Dehaen, Wim; Van Der Eycken, Erik Chemistry - A European Journal, 2007 , vol. 13, # 22 p. 6452 - 6460

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Citation Number: 49

Abstract

Abstract Two novel and efficient strategies for the synthesis of hitherto unknown N-shifted and ring-expanded buflavine analogues are presented. Construction of the medium-sized ring system of the title molecules, a difficult task due to the high activation energy needed for the ring-closure with the additional rigidity imposed by the biaryl skeleton, was achieved by using Suzuki–Miyaura biaryl coupling and a ring-closing metathesis reaction as the key ...