Total synthesis of myxovirescin A1
…, M Bonnekessel, JT Blank, K Radkowski…
Index: Fuerstner, Alois; Bonnekessel, Melanie; Blank, Jarred T.; Radkowski, Karin; Seidel, Guenter; Lacombe, Fabrice; Gabor, Barbara; Mynott, Richard Chemistry - A European Journal, 2007 , vol. 13, # 31 p. 8762 - 8783
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Citation Number: 51
Abstract
Abstract A convergent total synthesis of the antibiotic macrolide myxovirescin A 1 (1) is described that is largely based on reagent-and catalyst-controlled transformations. This includes a highly regioselective Negishi reaction of dibromo-alkene 48 with an alkynylzinc reagent, and a palladium catalyzed alkyl-Suzuki coupling of the resulting enyne derivative 12 with the 9-BBN-adduct derived from alkene 61. The latter was obtained via an ...
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