Chemistry Letters

Synthetic approach toward mitomycins. Efficient synthesis of mitosane precursors from (2, 4-pentadienyl)-p-quinones.

Y Naruta, Y Arita, N Nagai, H Uno, K Maruyama

Index: Naruta, Yoshinori; Arita, Yoshihiro; Nagai, Naoshi; Uno, Hidemitsu; Maruyama, Kazuhiro Chemistry Letters, 1982 , p. 1859 - 1862

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Abstract

Introduction of 2, 4-pentadienyl side chain to halogenated p-quinones is performed with (2, 4- pentadienyl) trimethylstannane to afford 2-halo-3-(2, 4-pentadienyl)-1, 4-quinones. Pyrolytic decomposition of the corresponding azidoquinones derived from the obtained haloquinones affords 3H-pyrrolo [1, 2-a] indol-5, 8-dione derivatives in good yields.