Synthesis and cytotoxic activity of hydroxylated derivatives of olivacine in relation with their biotransformation

M Maftouh, R Besselievre, B Monsarrat…

Index: Maftouh; Besselievre; Monsarrat; Lesca; Meunier; Husson; Paoletti Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 708 - 714

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Citation Number: 22

Abstract

The chemical synthesis of 9-hydroxyolivacine and 7-hydroxyolivacine based on a biomimetic approach is described. These two hydroxylated derivatives have been found as main in vitro metabolites of olivacine after incubation with rat hepatic microsomes. The pretreatment of animals with benzo [a] pyrene caused a large increase in both microsomal hydroxylations, whereas the pretreatment with phenobarbital caused a weak increase, ...