Nitrogen bridgehead compounds, Part 31 1H and 13C NMR study of tetra??and octahydro??11H??pyrido [2, 1??b] quinazolin??11??ones

I Hermecz, B Podányi, Z Mészáros…

Index: Hermecz; Podanyi; Meszaros; et al. Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 93 - 96

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Citation Number: 9

Abstract

Abstract Conformational analysis of some tetra-and octahydro-11H-pyrido [2, 1-b] quinazolin- 11-ones 1-3 by 1 H and 13 C nmr revealed that the 9-methyl-6, 7, 8, 9-tetrahydro derivative exists mainly in the conformation containing the methyl group in a quasi-axial orientation. Of the 1, 2, 3, 4, 5, 6, 7, 8-octahydro compounds, the 9-methyl derivative 3e contains the methyl group in a quasi-axial position, while that in the 7-methyl and the 8-methyl derivatives 3c, ...