Synlett

Synthesis of chiral γ-amino-β-hydroxyphosphonate derivatives from unsaturated phosphonates

T Yamagishi, K Fujii, S Shibuya, T Yokomatsu

Index: Yamagishi, Takehiro; Fujii, Keiichi; Shibuya, Shiroshi; Yokomatsu, Tsutomu Synlett, 2004 , # 14 p. 2505 - 2508

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Citation Number: 8

Abstract

Abstract γ-Amino-β-hydroxyphosphonates, useful intermediates for the synthesis of phosphonic acid analogues of carnitine, were prepared as their protected derivatives in an enantioselective manner from β, γ-unsaturated phosphonates through asymmetric dihydroxylation and subsequent regioselective amination via the cyclic sulfates.