Tetrahedron

α-Substituierte phosphonate—38: 1-dimethylamino-1-cyano-methanphosphonsäurediethylester, ein neues edukt zur darstellung von carbonsäuren, 1- …

B Costisella, H Gross

Index: Costisella, Burkhard; Gross, Hans Tetrahedron, 1982 , vol. 38, # 1 p. 139 - 145

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Citation Number: 3

Abstract

Alkylation of 1-dimethylamino-1-cyanomethanephosphonic acid diethyl ester (8), easily obtainable from diethyl phosphite and the 0, N-acetal 9, yields 1-alkyl derivatives 14. Elimination of HCN converts 14 into 1-phosphonoenamines 6. Carbonyl compounds react with 8 to give 1-cyanoenamines 15 which may be hydrolyzed to from the homologous carboxylic acid. Alternatively, deprotonation of 15 yields the homoenolate anions 17 which ...