Tetrahedron Letters

Reductive alkylation of 2-methoxybenzoic acid derivatives

JM Hook, LN Mander, M Woolias

Index: Hook, James M.; Mander, Lewis N.; Woolias, Michael Tetrahedron Letters, 1982 , vol. 23, # 10 p. 1095 - 1098

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Citation Number: 31

Abstract

Abstract Metal-ammonia reduction followed by in situ alkylation of 2-methoxybenzoic acids often results in substantial loss of the methoxy substituent; reduction of the carboxylate salts or esters, however, suppresses this side reaction and good to excellent yields of desired products are then obtained.