High yield acyl anion transfer reactions: nucleophilic acylation of aldehydes
D Seyferth, RM Weinstein, WL Wang, RC Hui
Index: Seyferth, Dietmar; Weinstein, Robert M.; Wang, Wei-Liang; Hui, Richard C. Tetrahedron Letters, 1983 , vol. 24, # 45 p. 4907 - 4910
Full Text: HTML
Citation Number: 27
Abstract
Abstract Aldehydes may be acylated to give R'CH (ON) C (O) R in good yield by the RLi/CO in situ procedure at very low temperatures. Examples are given of ketone acylations which demonstrate the advantages of 1: 1 RLi/substrate stoichiometry and the use of lower (− 135 C) temperature.
Related Articles:
Properties of. alpha.-keto cations. Facile generation under solvolytic conditions
[Creary,X.; Geiger,C.C. Journal of the American Chemical Society, 1982 , vol. 104, p. 4151]
Properties of. alpha.-keto cations. Facile generation under solvolytic conditions
[Creary,X.; Geiger,C.C. Journal of the American Chemical Society, 1982 , vol. 104, p. 4151]