Synthesis and biological properties of new 1β-methylcarbapenems

KJ Shin, KH Yoo, DJ Kim, SW Park, BS Ko…

Index: Shin, Kye Jung; Yoo, Kyung Ho; Kim, Dong Jin; Park, Sang Woo; Ko, Bong Suck; Lee, Sang Joo; Huh, Jae Doo; Park, Seung Yong Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 13 p. 1607 - 1612

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Citation Number: 10

Abstract

The synthesis and biological activity of the novel series of 1β-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2= NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety.