Copper??Mediated Deoxygenative Trifluoromethylation of Benzylic Xanthates: Generation of a C CF3 Bond from an O??Based Electrophile

…, S Liu, JT Douglas, RA Altman

Index: Zhu, Lingui; Liu, Shasha; Douglas, Justin T.; Altman, Ryan A. Chemistry - A European Journal, 2013 , vol. 19, # 38 p. 12800 - 12805

Full Text: HTML

Citation Number: 18

Abstract

Abstract The conversion of an alcohol-based functional group, into a trifluoromethyl analogue is a desirable transformation. However, few methods are capable of converting O- based electrophiles into trifluoromethanes. The copper-mediated trifluoromethylation of benzylic xanthates using Umemoto's reagent as the source of CF 3 to form C [BOND] CF 3 bonds is described. The method is compatible with an array of benzylic xanthates bearing ...