Double-head haptens. Synthesis of and experimentally induced contact sensitivity to substances containing two unrelated haptens, pyrocatechol and. alpha.- …

B Marchand, C Benezra

Index: Marchand, Bernard; Benezra, Claude Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 650 - 653

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Citation Number: 18

Abstract

Many pharmaceutical preparations, eg, perfumes and cosmetics, contain more than one contact sensitizer; this can result in simultaneous sensitization, a not uncommon phenomenon. This is known as “cosensitization”.l The clinical result (sensitivity to more than one allergen or hapten) is the expression of an antigenic competition at the molecular (hapten plus carrier) and cellular (on im- munologically competent cells) levels. Because the timing of sensitization ...