Organosilicon compounds with functional groups proximate to silicon. Feasible route to 1, 2-epoxyalkyllithium reagents via the lithiation of epoxyethylsilanes

JJ Eisch, JE Galle

Index: Eisch,J.J.; Galle,J.E. Journal of the American Chemical Society, 1976 , vol. 98, # 15 p. 4646 - 4648

Full Text: HTML

Citation Number: 77

Abstract

1 constitutes a valuable precursor to carbonyl, glycolic, and hydroxyalkyl functions, 2 as well as a fragment bearing two carbon centers of defined~ hirality.~ Despite their great potential in synthesis, up to the present metalated epoxides have not been prepared in any practical manner and have only been detected as transient intermediates in the reactions of strong bases with epoxides4 During a study of the reactions of organolithium reagents with ...