Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics

…, ASP Gowda, MA Crampsie, JK Yun, TE Spratt…

Index: Sk, Ugir Hossain; Prakasha Gowda; Crampsie, Melissa A.; Yun, Jong K.; Spratt, Thomas E.; Amin, Shantu; Sharma, Arun K. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 8 p. 3331 - 3338

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Citation Number: 14

Abstract

Abstract Synthesis and anti-melanoma activity of various naphthalimide analogs, rationally modified by introducing isothiocyanate (ITC) and thiourea (TU) functionalities, found in well- known anti-cancer agents, is described. The structure–activity relationship comparison of the novel agents in inhibiting cancer cell growth was evaluated in various melanoma cell lines. Both ITC and TU analogs effectively inhibited cell viability and induced apoptosis in ...