Rapid Assessment of Protecting??Group Stability by Using a Robustness Screen

KD Collins, A Rühling, F Lied…

Index: Collins, Karl D.; Ruehling, Andreas; Lied, Fabian; Glorius, Frank Chemistry - A European Journal, 2014 , vol. 20, # 13 p. 3800 - 3805

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Citation Number: 11

Abstract

Abstract An experimentally simple method has been developed to rapidly establish the stability of widely utilized silyl, acetal, and carbamate protecting groups to a given set of reaction conditions. Assessment of up to twelve protecting groups in a single experiment has been demonstrated. Evaluation of this protocol in two unrelated synthetic transformations suggests that this method can be used to select appropriate protecting groups in the ...