Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma

…, CM Napier, TA Payne-Cook, ER Renery…

Index: Millan, David S.; Ballard, Stephen A.; Chunn, Sara; Dybowski, Joseph A.; Fulton, Craig K.; Glossop, Paul A.; Guillabert, Edouard; Hewson, Christopher A.; Jones, Rhys M.; Lamb, David J.; Napier, Carolyn M.; Payne-Cook, Toby A.; Renery, Emmanuelle R.; Selby, Matthew D.; Tutt, Michelle F.; Yeadon, Michael Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5826 - 5830

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Citation Number: 10

Abstract

In this Letter we present data for a novel series of ICS for the treatment of asthma.'Inhalation by design'principles have been applied to a series of highly potent steroidal GR agonists, with a focus on optimising the potential therapeutic index in human. Pharmacokinetic ...