Tetrahedron letters

Regioselective cross-coupling reactions and nucleophilic aromatic substitutions on a 5, 7-dichloropyrido [4, 3-d] pyrimidine scaffold

MY Jang, S De Jonghe, LJ Gao, P Herdewijn

Index: Jang, Mi-Yeon; Jonghe, Steven De; Gao, Ling-Jie; Herdewijn, Piet Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8917 - 8920

Full Text: HTML

Citation Number: 14

Abstract

The synthesis of a 5, 7-dichloropyrido [4, 3-d] pyrimidine scaffold is described. The chlorine at position 5 can selectively be displaced by different palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitutions. In the subsequent step, the chlorine at position 7 can be further derivatized. The described synthetic sequence allows for the construction of a diverse pyrido [4, 3-d] pyrimidine library with structural variations at ...