… studies on selective type 4 phosphodiesterase (PDE 4) inhibitors. 1. Structure-activity relationships and pharmacological evaluation of 1, 8-naphthyridin-2 (1H)-one …

K Takayama, M Iwata, H Hisamichi, Y Okamoto…

Index: Takayama, Kazuhisa; Iwata, Masahiro; Hisamichi, Hiroyuki; Okamoto, Yoshinori; Aoki, Motonori; Niwa, Akira Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 8 p. 1050 - 1059

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Citation Number: 13

Abstract

In order to develop novel and orally active phosphodiesterase (PDE) 4 inhibitors, random screening was performed using our chemical library to find YM-10335 possessing the 1, 8- naphthyridin-2 (1H)-one skeleton which is a completely different structure from rolipram. In this report, the syntheses and structure–activity relationships of the YM-10335 derivatives were described. Some compounds showed selective inhibitory activities for PDE 4 derived ...