Synthesis and hepatic metabolism of xanthobilirubinic acid regioisomers

…, JO Brower, AF McDonagh, DA Lightner

Index: Boiadjiev, Stefan E.; Conley, Brian A.; Brower, Justin O.; McDonagh, Antony F.; Lightner, David A. Monatshefte fur Chemie, 2006 , vol. 137, # 11 p. 1463 - 1476

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Citation Number: 4

Abstract

Summary. A set of four regioisomeric dipyrrinone propionic acids has been synthesized and their hepatic metabolism examined in rats: xanthobilirubinic acid and pseudo- xanthobilirubinic acid each with a propionic acid on a pyrrole ring; exo-ψ-xanthobilirubinic acid and endo-ψ-xanthobilirubinic acid, each with a propionic acid transposed to a lactam ring. After intravenous injection all four isomers were excreted to some degree in ...