Synthesis and immunosuppressant activity of pyrazole carboxamides

…, KW Mollison, GC Hsieh, K Marsh, MP Sheets…

Index: Wang, Alan X.; Xie, Qinghua; Lane, Ben; Mollison, Karl W.; Hsieh, Gin C.; Marsh, Kennan; Sheets, Michael P.; Luly, Jay R.; Coghlan, Michael J. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 19 p. 2787 - 2792

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Citation Number: 26

Abstract

A series of novel pyrazole carboxamides is disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC50< 1 μM). The synthesis, biological activity, mode of action, and pharmacokinetic properties of this new lead series are discussed.