Metallo-β-lactamase inhibitory activity of phthalic acid derivatives

Y Hiraiwa, A Morinaka, T Fukushima, T Kudo

Index: Hiraiwa, Yukiko; Morinaka, Akihiro; Fukushima, Takayoshi; Kudo, Toshiaki Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 5162 - 5165

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Citation Number: 40

Abstract

4-Butyl-3-methylphthalic acid was recognized as a metallo-β-lactamase inhibitor. The structure–activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted with 4- hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1.