Synthesis and bioactivity study of 2, 5-bismercapto-1, 3, 4-thiadiazole heterocyclic derivatives

M Li, Y Zhang, T Wei

Index: Li, Man-Lin; Zhang, You-Ming; Wei, Tai-Bao Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 3 p. 544 - 549

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Citation Number: 11

Abstract

Abstract: A series of acylhydrazone compounds 3a-i and acylthiosemicarbazides 4a-h containing thiadiazole rings have been synthesized conveniently in high yields. Some heterocyclic derivatives 5 are prepared by the method of dehydration of compounds 4. Structure of all these compounds have been confirmed by elemental analysis, IR, ¹H and ¹³C NMR. The bioassay result indicates that some compounds have relatively low ...