Synthesis and anti-inflammatory activity of a series of mono-and bicyclic pyrazole derivatives

VG Granik, EO Sochneva, NL Solov'eva…

Index: Granik, V. G.; Sochneva, E. O.; Solov'eva, N. L.; Shvarts, G. Ya.; Syubaev, R. D.; Mashkovskii, M. D. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 6 p. 374 - 377 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 6 p. 36 - 40

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Abstract

The intent of the present work was to study the anti-inflammatory activity of the known compounds IIa, b, df, IIIa-c [i, 2], and to compare their activity with that of the corresponding N- phenyl analogs (IIc and IIId). In addition, the preparation of the corresponding isoxazole derivatives (IVa, b) also was undertaken.