Journal of inorganic biochemistry

Anticancer (hexacarbonyldicobalt) propargyl aryl ethers: synthesis, antiproliferative activity, apoptosis induction, and effect on cellular oxidative stress

SD Schimler, DJ Hall, SL Debbert

Index: Schimler, Sydonie D.; Hall, David J.; Debbert, Stefan L. Journal of Inorganic Biochemistry, 2013 , vol. 119, p. 28 - 37

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Citation Number: 14

Abstract

While an increasing number of (hexacarbonyldicobalt) alkynes have been found to possess antiproliferative activity against a number of cancer cell lines, the role of the organometallic moiety in this bioactivity is not well understood. To gain a better understanding of cobalt's role in the medicinal chemistry of these compounds, several simplified analogs of a known organocobalt anticancer compound were synthesized and assessed for antiproliferative ...