Non-peptide oxytocin agonists

G Pitt, A Batt, R Haigh, A Penson, P Robson…

Index: Pitt, Gary; Batt, Andrzej; Haigh, Robert; Penson, Andrew; Robson, Peter; Rooker, David; Tartar, Andre; Trim, Julie; Yea, Christopher; Roe, Michael Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4585 - 4589

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Citation Number: 45

Abstract

A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50= 33nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT).