Influence of trialkylsilyl-and silatranylmethylesters of aryloxy-, arylthio-, and arylaminoacetic acids on the aggregation of thrombocytes

TV Nefedova, B Shirchin, VB Kazimirovskaya…

Index: Nefedova, T. V.; Shirchin, B.; Kazimirovskaya, V. B.; Voronkov, M. G. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 3 p. 182 - 185 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 3 p. 319 - 321

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Abstract

The primary effect of chemical agents on cells is the disruption of the cell membrane [i]. In this connection, the search for membrane-stabilizing agents is of significant theoretical and practical interest. These materials are conveniently investigated by the ADP-induced aggregation of thromboeytes. Organic compounds of silicon significantly affecting the coagulation system of the blood are particularly attractive in the role of cell membrane ...