DBU-Promoted Facile, Chemoselective Cleavage of Acetylenic TMS Group
CE Yeom, MJ Kim, W Choi, BM Kim
Index: Yeom, Chang-Eun; Mi, Jeong Kim; Choi, Whail; Kim, B. Moon Synlett, 2008 , # 4 p. 565 - 568
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Citation Number: 10
Abstract
Abstract Acetylenic trimethylsilyl (TMS) groups were efficiently removed using 1, 8- diazabicyclo [5.4. 0] undec-7-ene (DBU). With either 1.0 or even 0.1 equivalents of DBU, smooth desilylation of various terminal acetylenic TMS groups was accomplished selectively in the presence of alkyl silyl ethers and other base-labile groups. Furthermore, more sterically hindered terminal acetylenic silyl groups such as TBDMS and TIPS remained ...
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