Biphenol-based phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of diethylzinc
A Alexakis, D Polet, S Rosset…
Index: Alexakis, Alexandre; Polet, Damien; Rosset, Stephane; March, Sebastien Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5660 - 5667
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Citation Number: 134
Abstract
Phosphoramidite ligands, based on ortho-substituted biphenols and a chiral amine, induce high enantioselectivities (ee's up to 99%) in the copper-catalyzed conjugate addition of dialkylzinc reagents to a variety of Michael acceptors. Particularly, the best reported ee's were obtained for acyclic nitroolefins.
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