Catalytic asymmetric Michael reactions with enamides as nucleophiles

…, R Matsubara, N Kawai, S Kobayashi

Index: Berthiol, Florian; Matsubara, Ryosuke; Kawai, Nobuyuki; Kobayashi, Shu Angewandte Chemie - International Edition, 2007 , vol. 46, # 41 p. 7803 - 7805

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Citation Number: 46

Abstract

The asymmetric Michael addition reaction is among the most powerful methods for the generation of enantiomerically enriched 1, 5-dicarbonyl compounds. As these compounds are of great synthetic interest, many chiral metal complexes have been developed for their enantioselective synthesis. Evans et al. reported the Michael addition of silicon enolates to alkylidenemalonates under the catalysis of a copper (II)–bisoxazoline complex. Although ...