Synthesis

Regioselectivity in cross-coupling reactions of 2, 6, 8-trichloro-9-(tetrahydropyran-2-yl) purine: Synthesis of 2, 6, 8-trisubstituted purine bases

M Hocek, R Pohl

Index: Hocek, Michal; Pohl, Radek Synthesis, 2004 , # 17 p. 2869 - 2876

Full Text: HTML

Citation Number: 28

Abstract

Abstract The regioselectivity of cross-coupling reactions (Pd-catalyzed Suzuki-Miyaura reactions with phenylboronic acid and Fe-catalyzed reactions with methylmagnesium chloride) of 2, 6, 8-trichloro-9-(tetrahydropyran-2-yl) purine with varying amounts of the organometallic reagent was studied. In general, the regioselectivity of these reactions was quite low giving mixtures of isomers of mono-, di-and trisubstituted products. Nevertheless, ...