Oxazolidinones as novel human CCR8 antagonists

…, GI Stevenson, DM Morrow, P Rao, C Nguyen…

Index: Jin, Jian; Wang, Yonghui; Wang, Feng; Kerns, Jeffery K.; Vinader, Victoria M.; Hancock, Ashley P.; Lindon, Matthew J.; Stevenson, Graeme I.; Morrow, Dwight M.; Rao, Parvathi; Nguyen, Cuc; Barrett, Victoria J.; Browning, Chris; Hartmann, Guido; Andrew, David P.; Sarau, Henry M.; Foley, James J.; Jurewicz, Anthony J.; Fornwald, James A.; Harker, Andy J.; Moore, Michael L.; Rivero, Ralph A.; Belmonte, Kristen E.; Connor, Helen E. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1722 - 1725

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Citation Number: 19

Abstract

High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.