Consequences of affinity in heterogeneous catalytic reactions: highly chemoselective hydrogenolysis of iodoarenes

…, C Mioskowski, G Djéga-Mariadassou…

Index: Ambroise, Yves; Mioskowski, Charles; Djega-Mariadassou, Gerald; Rousseau, Bernard Journal of Organic Chemistry, 2000 , vol. 65, # 21 p. 7183 - 7186

Full Text: HTML

Citation Number: 26

Abstract

The catalytic hydrodeiodination reaction using molecular hydrogen and Pd/C has been revisited. It is shown, for the first time, that the chemoselectivity of this reaction is controlled by the high affinity of the iodinated compound for the catalyst. This reaction is compatible with most easily reducible functional groups (nitro, aldehyde, olefin, etc.). Using this reaction, the first general method for tritium labeling of 3-(trifluoromethyl)-3-phenyldiazirine is ...