Recent progress on the iterative construction of 4-substituted-3-hydroxy benzoic acids from unsaturated aldehydes and dimethyl succinate
E Brenna, C Fuganti, V Perozzo, S Serra
Index: Brenna, Elisabetta; Fuganti, Claudio; Perozzo, Valentina; Serra, Stefano Tetrahedron, 1997 , vol. 53, # 44 p. 15029 - 15040
Full Text: HTML
Citation Number: 21
Abstract
An improvement of a known two step cyclization procedure, affording 4-aryl-3-hydroxy benzoic acid derivatives from 3-aryl-2, 3-unsaturated aldehydes and dimethyl succinate, is described. The high versatility of the synthetic procedure is shown, as the aryl substituent can be a benzene or naphthalene moiety, or an heteroaromatic ring. It can be applied iteratively to prepare p, p'-oligophenyl derivatives.
Related Articles:
Design, synthesis and identification of novel colchicine-derived immunosuppressant
[Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420]